Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.

doi:10.1038/jid.2008.171

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Article

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.

The Journal of investigative dermatology - 1 Jan 2009

Denton Christopher P, Khan Korsa, Hoyles Rachel K, Shiwen Xu, Leoni Patricia, Chen Yunliang, Eastwood Mark, Abraham David J

Abstract excerpt

Previous attempts to delete type II TGFbeta receptor (TbetaRII) in fibroblasts have precluded examination of adult mice due to early mortality. We have selectively deleted TbetaRII postnatally in differentiated connective tissue fibroblasts using an inducible Cre-Lox strategy. Tamoxifen-dependent Cre recombinase linked to a fibroblast-specific regulatory sequence from the proalpha2(I)collagen gene permitted...

Topics

Alleles
Animals
Biomechanical Phenomena
Cell Lineage
Cytoskeleton
Extracellular Signal-Regulated MAP Kinases
Female
Fibroblasts
Gene Deletion
Mice
Muscles
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Transforming Growth Factor beta

Signal Transduction

Skin

Wound Healing

Source

Open in PubMed

Identifiers

PMID: 18563179
DOI: 10.1038/jid.2008.171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.