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Article

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.

The Journal of investigative dermatology - 1 Jan 2009

Denton Christopher P, Khan Korsa, Hoyles Rachel K, Shiwen Xu, Leoni Patricia, Chen Yunliang, Eastwood Mark, Abraham David J

Abstract excerpt

Previous attempts to delete type II TGFbeta receptor (TbetaRII) in fibroblasts have precluded examination of adult mice due to early mortality. We have selectively deleted TbetaRII postnatally in differentiated connective tissue fibroblasts using an inducible Cre-Lox strategy. Tamoxifen-dependent Cre recombinase linked to a fibroblast-specific regulatory sequence from the proalpha2(I)collagen gene permitted...

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Identifiers

PMID: 18563179
DOI: 10.1038/jid.2008.171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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