Article
Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis.
The American journal of pathology - 1 May 2002
Zheng Bing, Zhang Zhaoping, Black Carol M, de Crombrugghe Benoit, Denton Christopher P
Abstract excerpt
Strategies for conditional induction of transgene expression in mice are likely to be valuable for testing the role of candidate genes in disease pathogenesis. We have developed a system for lineage-specific, ligand-dependent, induction of sustained transgene expression in fibroblastic cells in mice using a chimeric gene encoding the Cre-ER(T) fusion protein, under the control of a fibroblast-specific regulatory...
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