Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesodermal Deletion of Transforming Growth Factor-β Receptor II Disrupts Lung Epithelial Morphogenesis

7 Nov 2008

Abstract excerpt

In vertebrates, Sonic hedgehog (Shh) and transforming growth factor-beta (TGF-beta) signaling pathways occur in an overlapping manner in many morphogenetic processes. In vitro data indicate that the two pathways may interact. Whether such interactions occur during embryonic development remains unknown. Using embryonic lung morphogenesis as a model, we generated transgenic mice in which exon 2 of the TbetaRII...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Neonatal Respiratory Health Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18990706
DOI: 10.1074/jbc.m806786200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesodermal Deletion of Transforming Growth Factor-β Receptor II Disrupts Lung Epithelial MorphogenesisPMID 18990706Read ↗

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis.Semantic proximity Read ↗

Molecular embryology of the lung: then, now, and in the futureSemantic proximity Read ↗

Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.Semantic proximity Read ↗

The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesisSemantic proximity Read ↗

TGF‐β signaling is dynamically regulated during the alveolarization of rodent and human lungsSemantic proximity Read ↗

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilageSemantic proximity Read ↗

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.Semantic proximity Read ↗

TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.Semantic proximity Read ↗

Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.Semantic proximity Read ↗

Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4enhancerSemantic proximity Read ↗

Interaction of TGFβ and BMP Signaling Pathways during ChondrogenesisSemantic proximity Read ↗

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.