Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).

The Journal of biological chemistry - 22 Apr 2005

Denton Christopher P, Lindahl Gisela E, Khan Korsa, Shiwen Xu, Ong Voon H, Gaspar Nicholas J, Lazaridis Konstantinos, Edwards Dylan R, Leask Andrew, Eastwood Mark, Leoni Patricia, Renzoni Elisabetta A, Bou Gharios George, Abraham David J, Black Carol M

Abstract excerpt

We have generated transgenic mice expressing a kinase-deficient type II transforming growth factor-beta (TGFbeta) receptor selectively on fibroblasts (TbetaRIIDeltak-fib). These mice develop dermal and pulmonary fibrosis. In the present study we explore activation of TGFbeta signaling pathways in this strain and examine the profibrotic properties of explanted transgenic fibroblasts including myofibroblast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblasts
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Matrix Metalloproteinases

Share to Mice, Transgenic

Share to Phosphorylation

Share to Receptors, Transforming Growth Factor beta

Share to Smad Proteins

Share to Trans-Activators

Source

Identifiers

PMID: 15708853
DOI: 10.1074/jbc.M413134200

Genes

CCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).PMID 15708853Read ↗

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.Semantic proximity Read ↗

An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma.Semantic proximity Read ↗

An Essential Role for Resident Fibroblasts in Experimental Lung Fibrosis Is Defined by Lineage-Specific Deletion of High-Affinity Type II Transforming Growth Factor β ReceptorSemantic proximity Read ↗

Generation of mice with a conditional allele for transforming growth factor beta 1 gene.Semantic proximity Read ↗

Biology of TGF-β in knockout and transgenic mouse modelsSemantic proximity Read ↗

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.Semantic proximity Read ↗

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibitionSemantic proximity Read ↗

Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.Semantic proximity Read ↗

Function of cytokines within the TGF-beta superfamily as determined from transgenic and gene knockout studies in mice.Semantic proximity Read ↗

Expression of a truncated FGF receptor results in defective lens development in transgenic mice.Semantic proximity Read ↗

A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary glandSemantic proximity Read ↗

Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.