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Article

Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.

Journal of virology - 1 Sept 2008

Lakdawala Seema S, Schwartz Rachel A, Ferenchak Kevin, Carson Christian T, McSharry Brian P, Wilkinson Gavin W, Weitzman Matthew D

Abstract excerpt

Adenoviruses (Ad) with the early region E4 deleted (E4-deleted virus) are defective for DNA replication and late protein synthesis. Infection with E4-deleted viruses results in activation of a DNA damage response, accumulation of cellular repair factors in foci at viral replication centers, and joining together of viral genomes into concatemers. The cellular DNA repair complex composed of Mre11, Rad50, and Nbs1...

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Identifiers

PMID: 18562516
DOI: 10.1128/JVI.00900-08
PMCID: PMC2519655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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