Genome concatenation contributes to the late gene expression defect of an adenovirus E4 mutant.

Abstract excerpt

Adenovirus mutants that lack the entire E4 region are severely defective for late gene expression. E4 mutant genomes are also concatenated by host double strand break repair (DSBR) proteins. We find that E4 mutant late gene expression improves in MO59J cells that fail to form genome concatemers. DSBR kinase inhibitors interfere with genome concatenation and also stimulate late gene expression. Concatenation of E4...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adenoviridae
• Share to Androstadienes
• Share to DNA Repair Enzymes