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The Adenovirus E1b55K/E4orf6 Complex Induces Degradation of the Bloom Helicase during Infection

2 Dec 2010

Abstract excerpt

The adenovirus (Ad) E1b55K and E4orf6 gene products assemble an E3 ubiquitin ligase complex that promotes degradation of cellular proteins. Among the known substrates are p53 and the Mre11-Rad50-Nbs1 (MRN) complex. Since members of the RecQ helicase family function together with MRN in genome maintenance, we investigated whether adenovirus affects RecQ proteins. We show that Bloom helicase (BLM) is degraded...

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PMID: 21123383
DOI: 10.1128/jvi.02134-10

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The Adenovirus E1b55K/E4orf6 Complex Induces Degradation of the Bloom Helicase during InfectionPMID 21123383Read ↗

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