Article
Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 2010
Blackford Andrew N, Patel Rakesh N, Forrester Natalie A, Theil Kathrin, Groitl Peter, Stewart Grant S, Taylor A Malcolm R, Morgan Iain M, Dobner Thomas, Grand Roger J A, Turnell Andrew S
Abstract excerpt
Activation of the cellular DNA damage response is detrimental to adenovirus (Ad) infection. Ad has therefore evolved a number of strategies to inhibit ATM- and ATR-dependent signaling pathways during infection. Recent work suggests that the Ad5 E4orf3 protein prevents ATR activation through its ability to mislocalize the MRN complex. Here we provide evidence to indicate that Ad12 has evolved a different strategy...
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