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Article

Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirus mutants.

Journal of virology - 1 Dec 2012

Prakash Anand, Jayaram Sumithra, Bridge Eileen

Abstract excerpt

Adenovirus (Ad) mutants that lack early region 4 (E4) activate the phosphorylation of cellular DNA damage response proteins. In wild-type Ad type 5 (Ad5) infections, E1b and E4 proteins target the cellular DNA repair protein Mre11 for redistribution and degradation, thereby interfering with its ability to activate phosphorylation cascades important during DNA repair. The characteristics of Ad infection that...

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Identifiers

PMID: 23015708
DOI: 10.1128/JVI.01757-12
PMCID: PMC3503084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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