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Article

Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirus mutants.

Journal of virology - 1 Dec 2012

Prakash Anand, Jayaram Sumithra, Bridge Eileen

Abstract excerpt

Adenovirus (Ad) mutants that lack early region 4 (E4) activate the phosphorylation of cellular DNA damage response proteins. In wild-type Ad type 5 (Ad5) infections, E1b and E4 proteins target the cellular DNA repair protein Mre11 for redistribution and degradation, thereby interfering with its a...

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Identifiers

PMID: 23015708
DOI: 10.1128/JVI.01757-12
PMCID: PMC3503084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23015708-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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