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Article

Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form.

Human mutation - 1 Dec 2008

Mou Chunyan, Thomason Helen A, Willan Pamela M, Clowes Christopher, Harris W Edwin, Drew Caroline F, Dixon Jill, Dixon Michael J, Headon Denis J

Abstract excerpt

Hair morphology differs dramatically between human populations: people of East Asian ancestry typically have a coarse hair texture, with individual fibers being straight, of large diameter, and cylindrical when compared to hair of European or African origin. Ectodysplasin-A receptor (EDAR) is a cell surface receptor of the tumor necrosis factor receptor (TNFR) family involved in the development of hair follicles,...

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Source

Identifiers

PMID: 18561327
DOI: 10.1002/humu.20795

Genes

EDAR

Variants

rs3827760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form.PMID 18561327Read ↗

Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia.Semantic proximity Read ↗

A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness.Semantic proximity Read ↗

Modeling recent human evolution in mice by expression of a selected EDAR variant.Semantic proximity Read ↗

Molecular mechanisms underlying hair shape variation in the human populationSemantic proximity Read ↗

The adaptive variant EDARV370A is associated with straight hair in East Asians.Semantic proximity Read ↗

Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands.Semantic proximity Read ↗

EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects.Semantic proximity Read ↗

A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia.Semantic proximity Read ↗

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.Semantic proximity Read ↗

Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple DiseasesSemantic proximity Read ↗

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair.Semantic proximity Read ↗

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