Article
Selective advantages, selective mismatches, chronic inflammation, obesity, and type 2 diabetes: a new hypothesis to explain the effects of natural selection on genetic variation at the ectodysplasin A receptor locus.
BMJ open diabetes research & care - 8 Sept 2026
Coletta Dawn K, Hlusko Leslea J, Scott G Richard, Klimentidis Yann, Pastore Arielle, Palumbo Sunny, Fatima Nasrin, Mandarino Lawrence J
Abstract excerpt
Development of ectodermal tissues in humans is a complex process regulated by interacting signaling pathways. This review adopts an evolutionary medicine framework to examine how genetic variation in components of the ectodysplasin A (EDA) signaling pathway may have conferred human evolutionary fitness during the last ice age, but today may present an evolutionary mismatch, contributing to modern chronic...
Read the complete abstract on PubMedTopics
- Humans
- Inflammation
- Diabetes Mellitus, Type 2
- Selection, Genetic
- Obesity