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Article

Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands.

PloS one - 26 Oct 2009

Chang Shie Hong, Jobling Stephanie, Brennan Keith, Headon Denis J

Abstract excerpt

The skin carries a number of appendages, including hair follicles and a range of glands, which develop under the influence of EDAR signalling. A gain of function allele of EDAR is found at high frequency in human populations of East Asia, with genetic evidence suggesting recent positive selection at this locus. The derived EDAR allele, estimated to have reached fixation more than 10,000 years ago, causes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19855838
DOI: 10.1371/journal.pone.0007591
PMCID: PMC2762540

Genes

EDAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands.PMID 19855838Read ↗

Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form.Semantic proximity Read ↗

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Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia.Semantic proximity Read ↗

Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution.Semantic proximity Read ↗

Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology.Semantic proximity Read ↗

A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness.Semantic proximity Read ↗

Overexpression of Epigen during Embryonic Development Induces Reversible, Epidermal Growth Factor Receptor-Dependent Sebaceous Gland HyperplasiaSemantic proximity Read ↗

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A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia.Semantic proximity Read ↗

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