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Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases

10 Aug 2022

Abstract excerpt

Ectodysplasin A (EDA) signaling is initially identified as morphogenic signaling regulating the formation of skin appendages including teeth, hair follicles, exocrine glands in mammals, feathers in birds and scales in fish. Gene mutation in EDA signaling causes hypohidrotic ectodermal dysplasia (HED), a congenital hereditary disease with malformation of skin appendages. Interestingly, emerging evidence suggests...

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PMID: 36012178
DOI: 10.3390/ijms23168911

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