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Article

The adaptive variant EDARV370A is associated with straight hair in East Asians.

Human genetics - 1 Oct 2013

Tan Jingze, Yang Yajun, Tang Kun, Sabeti Pardis C, Jin Li, Wang Sijia

Abstract excerpt

Hair straightness/curliness is a highly heritable trait amongst human populations. Previous studies have reported European specific genetic variants influencing hair straightness, but those in East Asians remain unknown. One promising candidate is a derived coding variant of the ectodysplasin A receptor (EDAR), EDARV370A (370A), associated with several phenotypic changes of epidermal appendages. One of the...

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PMID: 23793515
DOI: 10.1007/s00439-013-1324-1

Genes

EDAR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The adaptive variant EDARV370A is associated with straight hair in East Asians.PMID 23793515Read ↗

Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.Semantic proximity Read ↗

EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects.Semantic proximity Read ↗

Molecular mechanisms underlying hair shape variation in the human populationSemantic proximity Read ↗

A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness.Semantic proximity Read ↗

Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form.Semantic proximity Read ↗

Common variants in the trichohyalin gene are associated with straight hair in Europeans.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair.Semantic proximity Read ↗

Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia.Semantic proximity Read ↗

Modeling recent human evolution in mice by expression of a selected EDAR variant.Semantic proximity Read ↗

A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia.Semantic proximity Read ↗

Multi-ancestry tandem repeat association study of hair colour using exome-wide sequencingSemantic proximity Read ↗

A Comprehensive Review of GWASs of Human Hair Traits.Semantic proximity Read ↗

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