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Article

A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness.

Human molecular genetics - 15 Mar 2008

Fujimoto Akihiro, Kimura Ryosuke, Ohashi Jun, Omi Kazuya, Yuliwulandari Rika, Batubara Lilian, Mustofa Mohammad Syamsul, Samakkarn Urai, Settheetham-Ishida Wannapa, Ishida Takafumi, Morishita Yasuyuki, Furusawa Takuro, Nakazawa Minato, Ohtsuka Ryutaro, Tokunaga Katsushi

Abstract excerpt

Hair morphology is one of the most differentiated traits among human populations. However, genetic backgrounds of hair morphological differences among populations have not been clarified yet. In addition, little is known about the evolutionary forces that have acted on hair morphology. To identify hair morphology-determining genes, the levels of local genetic differentiation in 170 genes that are related to hair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18065779
DOI: 10.1093/hmg/ddm355

Genes

EDAR

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A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness.PMID 18065779Read ↗

A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia.Semantic proximity Read ↗

FGFR2 is associated with hair thickness in Asian populations.Semantic proximity Read ↗

Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair.Semantic proximity Read ↗

Molecular mechanisms underlying hair shape variation in the human populationSemantic proximity Read ↗

EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects.Semantic proximity Read ↗

The adaptive variant EDARV370A is associated with straight hair in East Asians.Semantic proximity Read ↗

Modeling recent human evolution in mice by expression of a selected EDAR variant.Semantic proximity Read ↗

A common variation in EDAR is a genetic determinant of shovel-shaped incisors.Semantic proximity Read ↗

Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia.Semantic proximity Read ↗

Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits.Semantic proximity Read ↗

Overlapping association signals in the genetics of hair-related phenotypes in humans and their relevance to predictive DNA analysis.Semantic proximity Read ↗

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