Article
The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy.
Journal of medical genetics - 1 Dec 1998
de Franchis R, Buoninconti A, Mandato C, Pepe A, Sperandeo M P, Del Gado R, Capra V, Salvaggio E, Andria G, Mastroiacovo P
Abstract excerpt
OBJECTIVE: To estimate the risk for spina bifida associated with the common mutation C677T of the MTHFR gene in a country with a relatively low prevalence of NTDs. DESIGN: Case-control study. SUBJECTS: CASES: 203 living patients affected with spina bifida (173 myelomeningocele and 30 lipomeningoc...
Topics
- 5,10-Methylenetetrahydrofolate Reductase (FADH2)
- Adult
- Case-Control Studies
- Child
- Cysteine
- Genotype
- Humans
- Infant, Newborn
- Italy
- Meta-Analysis as Topic
- Methylenetetrahydrofolate Dehydrogenase (NAD+)
- Methylenetetrahydrofolate Dehydrogenase (NADP)
- Methylenetetrahydrofolate Reductase (NADPH2)