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Article

Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida.

American journal of obstetrics and gynecology - 1 Oct 2009

Martinez Carla A, Northrup Hope, Lin Jone-Ing, Morrison Alanna C, Fletcher Jack M, Tyerman Gayle H, Au Kit Sing

Abstract excerpt

OBJECTIVE: We tested putative functional single nucleotide polymorphisms (SNPs) in genes that regulate the folate/homocysteine metabolism pathway for their contribution to spina bifida (SB) susceptibility. STUDY DESIGN: The study consisted of 610 unrelated simplex SB patient families. Genotypes of 46 SNPs located in the coding sequence or promoter region of 11 genes were investigated. Associations between...

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Share to Cystathionine beta-Synthase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

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Share to Thymidylate Synthase

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Identifiers

PMID: 19683694
DOI: 10.1016/j.ajog.2009.06.042
PMCID: PMC2790326

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