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Article

An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).

Birth defects research. Part A, Clinical and molecular teratology - 1 Mar 2009

Franke Barbara, Vermeulen Sita H H M, Steegers-Theunissen Regine P M, Coenen Marieke J, Schijvenaars Mascha M V A P, Scheffer Hans, den Heijer Martin, Blom Henk J

Abstract excerpt

BACKGROUND: Spina bifida is a class of neural tube defects, which are congenital malformations of the central nervous system with a prevalence of 0.5 to 12 per 1000 births globally. In this article we attempt to identify genes related to folate and its metabolic pathways that are involved in the etiology of spina bifida. METHODS: We selected 50 folate metabolism-related genes and genotyped polymorphisms in those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19161160
DOI: 10.1002/bdra.20556

Genes

CUBN
TRDMT1
SARDH
RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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