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Article

Isolation and characterization of fission yeast sns mutants defective at the mitosis-to-interphase transition.

Genetics - 1 Apr 1998

Matynia A, Mueller U, Ong N, Demeter J, Granger A L, Hinata K, Sazer S

Abstract excerpt

pim1-d1ts was previously identified in a visual screen for fission yeast mutants unable to complete the mitosis-to-interphase transition. pim1+ encodes the guanine nucleotide exchange factor (GEF) for the spi1 GTPase. Perturbations of this GTPase system by either mutation or overproduction of its regulatory proteins cause cells to arrest with postmitotic condensed chromosomes, an unreplicated genome, and a wide...

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Identifiers

PMID: 9560394
DOI: 10.1093/genetics/148.4.1799
PMCID: PMC1460064

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