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Article

Dominant mutants identify new roles for p34cdc2 in mitosis.

The EMBO journal - 15 May 1995

Labib K, Craven R A, Crawford K, Nurse P

Abstract excerpt

A large number of dominant mutants have been generated in the fission yeast cdc2 gene, causing lethality when expressed in wild-type cells. The mutants interfere with distinct aspects of p34cdc2 function, producing one of four different phenotypes: mitotic arrest, multiple rounds of S phase in the absence of mitosis, premature mitosis or G2 arrest. The mitotic mutants DL41, DL45 and DL50 are characterized in this...

Topics

CDC2 Protein Kinase
Chromatids
Chromosomes, Fungal
Fungal Proteins
Genes, Fungal
Genes, Lethal
Genes, Regulator
Mitosis
Mutation
Phenotype
Promoter Regions, Genetic
Schizosaccharomyces

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizosaccharomyces pombe Proteins

Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7774573
DOI: 10.1002/j.1460-2075.1995.tb07209.x
PMCID: PMC398321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7774573-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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