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Article

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 1995

Demeter J, Morphew M, Sazer S

Abstract excerpt

Members of the RCC1 protein family are chromatin-associated guanine nucleotide exchange factors that have been implicated in diverse cellular processes in various organisms, yet no consensus has been reached as to their primary biological role. The fission yeast Schizosaccharomyces pombe, a single-celled eukaryote, provides an in vivo system in which to study the RCC1/Ran switch by using a temperature-sensitive...

Topics

Chromatin
Fungal Proteins
GTP-Binding Proteins
Genes, Fungal
Mitosis
Mutation
Nuclear Envelope
Nuclear Proteins
Schizosaccharomyces

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7877997
DOI: 10.1073/pnas.92.5.1436
PMCID: PMC42534

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7877997-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.PMID 7877997Read ↗

Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.Semantic proximity Read ↗

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.Semantic proximity Read ↗

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.Semantic proximity Read ↗

Partitioning and remodeling of the Schizosaccharomyces japonicus mitotic nucleus require chromosome tethers.Semantic proximity Read ↗

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.Semantic proximity Read ↗

A mutation in the gene involved in sister chromatid separation causes a defect in nuclear mRNA export in fission yeast.Semantic proximity Read ↗

The protein kinase kin1 is required for cellular symmetry in fission yeast.Semantic proximity Read ↗

Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway.Semantic proximity Read ↗

An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin.Semantic proximity Read ↗

The Ran GTPase cycle is required for yeast nuclear pore complex assembly.Semantic proximity Read ↗

Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast.Semantic proximity Read ↗

The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport.Semantic proximity Read ↗

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