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Article

Spi1 GTPase interacts with RCC1 to maintain interdependency of cell cycle events.

Princess Takamatsu symposia - 1 Jan 1991

Matsumoto T, Beach D

Abstract excerpt

A mutant which can enter mitosis at any cell cycle stage has been isolated and characterized in fission yeast. The pim1 (premature initiation of mitosis) mutant prearrested at G1/S can develop a mitotic spindle and has tightly condensed chromosomes upon shift to the restrictive temperature. pim1-induced mitosis requires maturation promoting factor (MPF) activity, but not the essential mitotic inducer, cdc25. The...

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Source

Identifiers

PMID: 1844237

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spi1 GTPase interacts with RCC1 to maintain interdependency of cell cycle events.PMID 1844237Read ↗

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.Semantic proximity Read ↗

Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase.Semantic proximity Read ↗

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.Semantic proximity Read ↗

Isolation and characterization of fission yeast sns mutants defective at the mitosis-to-interphase transition.Semantic proximity Read ↗

Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.Semantic proximity Read ↗

Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences.Semantic proximity Read ↗

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.Semantic proximity Read ↗

The spil GTPase interacts with RCCl in cell cycle dependency.Semantic proximity Read ↗

mik1(+) G1-S transcription regulates mitotic entry in fission yeast.Semantic proximity Read ↗

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.Semantic proximity Read ↗

The yeast SRM1 protein and human RCC1 protein share analogous functions.Semantic proximity Read ↗

An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome.Semantic proximity Read ↗

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