Article
Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.
Eukaryotic cell - 1 Oct 2006
Sotelo Jael, Rodríguez-Gabriel Miguel A
Abstract excerpt
Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.
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