Article
Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations.
Cancer research - 1 Aug 1991
Hollstein M C, Peri L, Mandard A M, Welsh J A, Montesano R, Metcalf R A, Bak M, Harris C C
Abstract excerpt
Esophageal squamous cell carcinoma (ESC) samples from patients residing in Uruguay and in Normandy, France, where alcoholic beverages and tobacco smoke are major risk factors, were analyzed for point mutations in the p53 tumor suppressor gene. Among 34 tumors (15 from Normandy and 19 from Uruguay...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Carcinoma, Squamous Cell
- Codon
- DNA Damage
- Esophageal Neoplasms
- Female
- France
- Genes, p53
- Genes, ras
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Uruguay