Article
TP53 mutation profile of esophageal squamous cell carcinomas of patients from Southeastern Brazil.
Mutation research - 1 Feb 2010
Rossini Ana, de Almeida Simão Tatiana, Marques Cynthia B, Soares-Lima Sheila C, Herbster Suellen, Rapozo Davy Carlos M, Andreollo Nelson A, Ferreira Maria A, El-Jaick Kenya Balbi, Teixeira Roberto, Guimarães Denise P, Albano Rodolpho Mattos, Ribeiro Pinto Luis Felipe
Abstract excerpt
Esophageal cancer (EC) is among the 10 most common and fatal malignacies in the world, presenting a marked geographic variation in incidence rates between and within different countries. The TP53 tumor suppressor gene is highly mutated in esophageal tumors and its mutation pattern can offer clues to the etiopathology of the tumor. As Brazil presents one of the highest incidence areas in the West, a deeper...
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