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Article

High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis.

Carcinogenesis - 1 Apr 2000

Robert V, Michel P, Flaman J M, Chiron A, Martin C, Charbonnier F, Paillot B, Frebourg T

Abstract excerpt

Somatic mutations of the tumor suppressor gene p53 have been frequently detected in esophagal cancers, but their biological significance remains to be established. The tumor suppressor activity of p53 results in part from its ability to transactivate genes involved in the cell cycle and apoptosis, such as p21, bax and PIG3, and some p53 mutations may have a differential effect on the transactivation of these...

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

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Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 10753186
DOI: 10.1093/carcin/21.4.563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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