Article
Testing for genetic association: a powerful score test.
Statistics in medicine - 30 Sept 2008
El Galta R, Stijnen T, Houwing-Duistermaat J J
Abstract excerpt
To study the association between a candidate gene and a complex genetic disease, Pearson's chi2 statistic can be applied to an mx2 contingency table, where the m categories correspond to m haplotypes or marker alleles. For m>2, two alternative approaches for Pearson's chi2 can be followed, which are more powerful if one haplotype or marker allele is associated. For the first approach, various 2x2 tables are...
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