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Article

Score statistic to test for genetic correlation for proband-family design.

Annals of human genetics - 1 Jul 2005

el Galta R, van Duijn C M, van Houwelingen J C, Houwing-Duistermaat J J

Abstract excerpt

In genetic epidemiological studies informative families are often oversampled to increase the power of a study. For a proband-family design, where relatives of probands are sampled, we derive the score statistic to test for clustering of binary and quantitative traits within families due to genetic factors. The derived score statistic is robust to ascertainment scheme. We considered correlation due to unspecified...

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Identifiers

PMID: 15996166
DOI: 10.1046/j.1529-8817.2005.00177.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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