Article
Generalizing Terwilliger's likelihood approach: a new score statistic to test for genetic association.
BMC genetics - 24 Sept 2007
el Galta Rachid, Uitte de Willige Shirley, de Visser Marieke C H, Helmer Quinta, Hsu Li, Houwing-Duistermaat Jeanine J
Abstract excerpt
BACKGROUND: In this paper, we propose a one degree of freedom test for association between a candidate gene and a binary trait. This method is a generalization of Terwilliger's likelihood ratio statistic and is especially powerful for the situation of one associated haplotype. As an alternative to the likelihood ratio statistic, we derive a score statistic, which has a tractable expression. For haplotype...
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