Article
Power comparisons between similarity-based multilocus association methods, logistic regression, and score tests for haplotypes.
Genetic epidemiology - 1 Apr 2009
Lin Wan-Yu, Schaid Daniel J
Abstract excerpt
Recently, a genomic distance-based regression for multilocus associations was proposed (Wessel and Schork [2006] Am. J. Hum. Genet. 79:792-806) in which either locus or haplotype scoring can be used to measure genetic distance. Although it allows various measures of genomic similarity and simultaneous analyses of multiple phenotypes, its power relative to other methods for case-control analyses is not well known....
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