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Article

Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.

Gastroenterology - 1 Jun 2008

Park Seung Woo, Davison Jon M, Rhee Jerry, Hruban Ralph H, Maitra Anirban, Leach Steven D

Abstract excerpt

BACKGROUND & AIMS: Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18549880
DOI: 10.1053/j.gastro.2008.02.084
PMCID: PMC2654247

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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