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Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

4 Jan 2021

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of ‘cancer stem cells (CSCs)’ in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk1), known as a CSC marker of PDAC. Using genetic lineage tracing with a dual-recombinase system and live imaging, we...

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PMID: 33393460
DOI: 10.7554/elife.55117

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