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Article

Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey.

Oncogene - 21 May 2015

Park J T, Johnson N, Liu S, Levesque M, Wang Y J, Ho H, Huso D, Maitra A, Parsons M J, Prescott J D, Leach S D

Abstract excerpt

Somatic activation of the KRAS proto-oncogene is evident in almost all pancreatic cancers, and appears to represent an initiating event. These mutations occur primarily at codon 12 and less frequently at codons 13 and 61. Although some studies have suggested that different KRAS mutations may have variable oncogenic properties, to date there has been no comprehensive functional comparison of multiple KRAS...

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Identifiers

PMID: 25065594
DOI: 10.1038/onc.2014.223
PMCID: PMC4836617

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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