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Article

Double Positive CD4+CD8+ (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C.

Cells - 22 May 2023

Kochanowicz Anna Maria, Osuch Sylwia, Berak Hanna, Kumorek Aleksandra, Caraballo Cortés Kamila

Abstract excerpt

In chronic hepatitis C (CHC), characterized by exhaustion of T-cell function, increased frequencies of double-positive (DP) (CD4+CD8+) cells are present in peripheral blood. We compared the exhaustion phenotype between DP and single positive (SP) T-cells, including HCV-specific cells, and assessed the effect of successful HCV treatment on inhibitory receptors expression. Blood samples from 97 CHC patients were...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37408280
DOI: 10.3390/cells12101446
PMCID: PMC10217244

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