Article
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2008
Rutebemberwa Alleluiah, Ray Stuart C, Astemborski Jacquie, Levine Jordana, Liu Lin, Dowd Kimberly A, Clute Shalyn, Wang Changyu, Korman Alan, Sette Alessandro, Sidney John, Pardoll Drew M, Cox Andrea L
Abstract excerpt
Hepatitis C virus (HCV) is an important human pathogen that represents a model for chronic infection given that the majority of infected individuals fail to clear the infection despite generation of virus-specific T cell responses during the period of acute infection. Although viral sequence evolution at targeted MHC class I-restricted epitopes represents one mechanism for immune escape in HCV, many targeted...
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