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Article

Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.

The Journal of biological chemistry - 1 Aug 2003

Duan Lei, Miura Yuko, Dimri Manjari, Majumder Biswanath, Dodge Ingrid L, Reddi Alagarsamy L, Ghosh Amiya, Fernandes Norvin, Zhou Pengcheng, Mullane-Robinson Karen, Rao Navin, Donoghue Stephen, Rogers Rick A, Bowtell David, Naramura Mayumi, Gu Hua, Band Vimla, Band Hamid

Abstract excerpt

Ligand-induced down-regulation controls the signaling potency of the epidermal growth factor receptor (EGFR/ErbB1). Overexpression studies have identified Cbl-mediated ubiquitinylation of EGFR as a mechanism of ligand-induced EGFR down-regulation. However, the role of endogenous Cbl in EGFR down-regulation and the precise step in the endocytic pathway regulated by Cbl remain unclear. Using Cbl-/- mouse embryonic...

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Share to Embryo, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to Epidermal Growth Factor

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Share to Proto-Oncogene Proteins c-cbl

Share to Retroviridae Proteins, Oncogenic

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Source

Identifiers

PMID: 12754251
DOI: 10.1074/jbc.M304474200

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.PMID 12754251Read ↗

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.Semantic proximity Read ↗

A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.Semantic proximity Read ↗

Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.Semantic proximity Read ↗

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.Semantic proximity Read ↗

The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor.Semantic proximity Read ↗

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.Semantic proximity Read ↗

Upregulation of E3 Ubiquitin Ligase CBLC Enhances EGFR Dysregulation and Signaling in Lung AdenocarcinomaSemantic proximity Read ↗

Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.Semantic proximity Read ↗

c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes.Semantic proximity Read ↗

Drosophila cbl is essential for control of cell death and cell differentiation during eye development.Semantic proximity Read ↗

The Cbl RING finger C-terminal flank controls epidermal growth factor receptor fate downstream of receptor ubiquitination.Semantic proximity Read ↗

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.Semantic proximity Read ↗

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