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Article

Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch.

Cell reports - 29 Aug 2013

Puliyappadamba Vineshkumar Thidil, Chakraborty Sharmistha, Chauncey Sandili S, Li Li, Hatanpaa Kimmo J, Mickey Bruce, Noorani Shayan, Shu Hui-Kuo G, Burma Sandeep, Boothman David A, Habib Amyn A

Abstract excerpt

RIP1 is a central mediator of cell death in response to cell stress but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 acts as a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is coexpressed with EGFRWT in glioblastoma multiforme (GBM). EGFRvIII recruits ubiquitin ligases to RIP1, resulting in K63-linked ubiquitination of RIP1. RIP1 binds...

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Source

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Identifiers

PMID: 23972990
DOI: 10.1016/j.celrep.2013.07.025
PMCID: PMC3780989

Genes

EGF
EGFR
FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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