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Article

Shooting the messenger: CULLIN' insulin signaling with Fbw8.

Developmental cell - 1 Jun 2008

Mieulet Virginie, Lamb Richard F

Abstract excerpt

When phosphorylated by mTORC1/S6K, the insulin receptor substrate (IRS-1) is targeted for ubiquitination and proteasomal degradation. In a recent issue of Molecular Cell, Xu et al. reveal that the E3 ubiquitin-ligase CUL7/Fbw8 targets IRS-1 for degradation, thereby implicating this enzyme in the regulation of insulin signaling.

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Share to Cullin Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

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Source

Identifiers

PMID: 18539111
DOI: 10.1016/j.devcel.2008.05.010

Genes

CUL7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Shooting the messenger: CULLIN' insulin signaling with Fbw8.PMID 18539111Read ↗

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