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Article

The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.

Molecular cell - 23 May 2008

Xu Xinsong, Sarikas Antonio, Dias-Santagata Dora C, Dolios Georgia, Lafontant Pascal J, Tsai Shih-Chong, Zhu Wuqiang, Nakajima Hidehiro, Nakajima Hisako O, Field Loren J, Wang Rong, Pan Zhen-Qiang

Abstract excerpt

Recent genetic studies have documented a pivotal growth-regulatory role played by the Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting subunit, Skp1, and the ROC1 RING finger protein. In this report, we identified insulin receptor substrate 1 (IRS-1), a critical...

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Source

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Identifiers

PMID: 18498745
DOI: 10.1016/j.molcel.2008.03.009
PMCID: PMC2633441

Genes

CUL7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18498745-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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