Article
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Science (New York, N.Y.) - 12 Sept 2008
Mao Jian-Hua, Kim Il-Jin, Wu Di, Climent Joan, Kang Hio Chung, DelRosario Reyno, Balmain Allan
Abstract excerpt
The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases, including cancer, but very little is known about the processes that control levels of mTOR protein. Here, we show that mTOR is targeted for ubiquitination and consequent de...
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