Article

USP1 deubiquitinates protein kinase Akt to inhibit PI3K-Akt-FoxO signaling

2019-05-30

Abstract excerpt

<h4>ABSTRACT</h4> PI3K-Akt-FoxO-mTOR signaling is the central pathway controlling growth and metabolism in all cells. Activation of this pathway requires ubiquitination of Akt prior to its activation by phosphorylation. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63-linked polyubiquitin chains on Akt to sustain PI3K-Akt-FoxO signaling low during prolonged starvation. DUB screening platform...

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Literature Corpus work: d121f984-f7c8-5345-b335-4c8ad91bf368
DOI: 10.1101/654921

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