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Article

Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.

Molecular and cellular biology - 1 Aug 2006

Tsunematsu Ryosuke, Nishiyama Masaaki, Kotoshiba Shuhei, Saiga Toru, Kamura Takumi, Nakayama Keiichi I

Abstract excerpt

Cullin-based ubiquitin ligases (E3s) constitute one of the largest E3 families. Fbxw8 (also known as Fbw6 or Fbx29) is an F-box protein that is assembled with Cul7 in an SCF-like E3 complex. Here we show that Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8. We generated mice deficient in Fbxw8 and found that Cul7 did not associate with Cul1 in cells of these mice. Two-thirds of...

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Identifiers

PMID: 16880526
DOI: 10.1128/MCB.00595-06
PMCID: PMC1592786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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