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The Cullin7 E3 ubiquitin ligase: A novel player in growth control

15 Oct 2008

Abstract excerpt

Cullin7 (CUL7) is a molecular scaffold that organizes an E3 ubiquitin ligase containing the F-box protein Fbw8, Skp1 and the ROC1 RING finger protein. Dysregulation of the CUL7 E3 Ligase has been directly linked to hereditary human diseases as cul7 germline mutations were found in patients with autosomal-recessive 3-M and Yakuts short stature syndromes, which are characterized by profound pre- and postnatal...

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PMID: 18927510
DOI: 10.4161/cc.7.20.6922

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