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Article

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

The Journal of biological chemistry - 29 May 2015

Koo Junghui, Wu Xiaoyun, Mao Zixu, Khuri Fadlo R, Sun Shi-Yong

Abstract excerpt

Rictor, an essential component of mTOR complex 2 (mTORC2), plays a pivotal role in regulating mTOR signaling and other biological functions. Posttranslational regulation of rictor (e.g. via degradation) and its underlying mechanism are largely undefined and thus are the focus of this study. Chemical inhibition of the proteasome increased rictor ubiquitination and levels. Consistently, inhibition of FBXW7 with...

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Source

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Identifiers

PMID: 25897075
DOI: 10.1074/jbc.M114.633057
PMCID: PMC4447982

Genes

SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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