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Article

The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.

Molecular cell - 6 Jun 2008

Kaplan Craig D, Larsson Karl-Magnus, Kornberg Roger D

Abstract excerpt

Structural, biochemical, and genetic studies have led to proposals that a mobile element of multisubunit RNA polymerases, the Trigger Loop (TL), plays a critical role in catalysis and can be targeted by antibiotic inhibitors. Here we present evidence that the Saccharomyces cerevisiae RNA Polymera...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18538653
DOI: 10.1016/j.molcel.2008.04.023
PMCID: PMC2475549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18538653-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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