Article
X-ray structure of a protease-resistant mutant form of human galectin-9 having two carbohydrate recognition domains with a metal-binding site.
Biochemical and biophysical research communications - 2 Sept 2017
Yoshida Hiromi, Nishi Nozomu, Wada Kenji, Nakamura Takanori, Hirashima Mitsuomi, Kuwabara Naoyuki, Kato Ryuichi, Kamitori Shigehiro
Abstract excerpt
Galectin-9 (G9) is a tandem-repeat type β-galactoside-specific animal lectin having N-terminal and C-terminal carbohydrate recognition domains (N-CRD and C-CRD, respectively) joined by a linker peptide that is involved in the immune system. G9 is divalent in glycan binding, and structural information about the spatial arrangement of the two CRDs is very important for elucidating its biological functions. As G9 is...
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