Article
Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.
Protein and peptide letters - 1 Jan 2007
Rojo-Domínguez Arturo, Ramírez-Galicia Guillermo, Havel Josef, Gutiérrez-González Luis Horacio
Abstract excerpt
S14G-humanin (S14G-HN) is one of the latest of a new family of neuropeptides with protective action against Alzheimer's disease insults. The structure of S14G-HN was studied with both spectroscopic techniques and molecular dynamics simulation. Secondary structure predictions and modeling of backbone conformation were carried out. Side chain reconstruction, homology modeling and molecular dynamics (MD) simulations...
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