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Article

Identification of the rare EGFR mutation p.G796S as somatic and germline mutation in white patients with squamous cell carcinoma of the head and neck.

Head & neck - 1 Aug 2008

Schwentner Ilona, Witsch-Baumgartner Martina, Sprinzl Georg M, Krugmann Jens, Tzankov Alexandar, Jank Siegfried, Zwierzina Heinz, Loeffler-Ragg Judith

Abstract excerpt

BACKGROUND: Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) are involved in tumorigenesis and response to targeted therapies in distinct cancer types. Squamous cell carcinomas of the head and neck (HNSCC) show an incidence of EGFR mutations varying from 7% in Asians to 0% to 4% in white patients. Mutational screening predominantly focuses on the analysis of hotspot...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18528899
DOI: 10.1002/hed.20831

Genes

EGFR

Variants

Provenance

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