Article
Involvement of EGFR in the response of squamous cell carcinoma of the head and neck cell lines to gefitinib.
Oncology reports - 1 Jan 2008
Taguchi Takahide, Tsukuda Mamoru, Imagawa-Ishiguro Yukari, Kato Yasumasa, Sano Daisuke
Abstract excerpt
Epidermal growth factor receptor (EGFR) gene mutations are associated with the sensitivity of non-small cell lung carcinomas (NSCLCs) to gefitinib, but such findings have not been reported in squamous cell carcinomas of the head and heck (SCCHNs). Accordingly, we determined whether EGFR gene expression and mutations correlate with the in vitro efficacy of gefitinib in SCCHN cell lines. EGFR status was analyzed in...
Topics
- Antineoplastic Agents
- Base Sequence
- Blotting, Western
- Carcinoma, Squamous Cell
- Cell Line, Tumor
- Cell Proliferation
- Drug Resistance, Neoplasm
- ErbB Receptors
- Gefitinib
- Gene Expression
- Head and Neck Neoplasms
- Humans
- Inhibitory Concentration 50
- Molecular Sequence Data
- Mutation
- Quinazolines
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction