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Article

Characterization of epidermal growth factor receptor mutations in non-small-cell lung cancer patients of African-American ancestry.

Oncogene - 14 Apr 2011

Harada T, Lopez-Chavez A, Xi L, Raffeld M, Wang Y, Giaccone G

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutations are predictive markers for response to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in non-small-cell lung cancer (NSCLC). The most common mutations, exon 19 short deletions and exon 20 point mutation (L858R), activate the tyrosine kinase and confer sensitivity to EGFR-TKIs. However, the function and sensitivity of rare mutations to EGFR-TKIs are unknown. In this...

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Identifiers

PMID: 21132006
DOI: 10.1038/onc.2010.545
PMCID: PMC7213757

Genes

EGFR

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